12-09

Complete deracemization of proteinogenic glutamic acid using Viedma ripening on a metastable conglomerate, Cryst. Growth Des. 12 (2012) 5796-5799

L. Spix, H. Meekes, R.H. Blaauw, W.J.P. van Enckevort and E. Vlieg

Abstract: Viedma ripening is a process in which a compound that forms a stable racemic conglomerate can be converted to an enantiomerically pure solid state. Combining this deracemization process with Ostwald’s rule of stages, allows Viedma ripening to be extended to a racemic compound for which the conglomerate exists only in a metastable form. This is demonstrated for glutamic acid, a proteinogenic amino acid. Since Ostwald ripening is one of the processes occurring during Viedma ripening, we thus make use of Ostwald twice.