Alexander B. C. Deutman, Cyrille Monnereau, Mohamed Moalin, Ruud G. E.
Coumans, Nico Veling, Michiel Coenen, Jan M. M. Smits, René de
Gelder, Johannes A. A. W. Elemans, Gianfranco Ercolani, Roeland J. M.
Nolte and Alan E. Rowan
Squaring
cooperative binding circles
Abstract:
The cooperative binding effects of viologens and pyridines to a
synthetic bivalent porphyrin receptor are used as a model system to
study how the magnitudes of these effects relate to the experimentally
obtained values. The full thermodynamic and kinetic circles concerning
both activation and inhibition of the cage of the receptor for the
binding of viologens were measuredand evaluated. The results strongly
emphasize the apparent character of measured binding and rate
constants, in which the fractional saturation of receptors with other
guests is linearly expressed in these constants. The presented method
can be used as a simple tool to better analyze and comprehend the
experimentally observed kinetics and thermodynamics
of natural and artificial cooperative systems.