Emergence
of a single solid chiral state from a nearly racemic amino acid
derivative
Noorduin WL , Izumi T, Millemaggi A ,
Leeman M , Meekes H , Van Enckevort WJP , Kellogg RM , Kaptein B, Vlieg
E , Blackmond DG
J. Am. Chem. Soc.130 no. 4 (2008)
1158-1159
Abstract:
The evolution of a single chiral solid state is reported for an
amino acid derivative starting from a nearly racemic mixture of solid
left- and right-handed crystals. Attrition-enhanced dissolution and
recrystallization processes based on solubility considerations of the
Gibbs-Thomson rule, coupled with solution-phase racemization, drive
this near-equilibrium system inexorably to single chirality in the
solid phase.