Understanding the effect of a solvent
on the crystal habit
Stoica C,
Verwer P, Meekes H, van Hoof PJCM, Kaspersen FM, Vlieg E
Cryst.
Growth & Design 4, 4 (2004) 765-768
Abstract:
The extreme polar morphology that has been observed for crystals of the
stable form of a steroid is explained by a molecular dynamics
simulations approach. The habit modification is caused by
surface-solvent interactions, which affect the growth rate of the polar
faces differently. The same effect was observed for the metastable
polymorphic form. Depending on the solvent, the nature of the
difference is mainly caused by the hydrogen bond interactions or the
electrostatic part of the interactions.